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Psoriasis & Genes

Psoriasis & Genes

Although people with no family history of psoriasis can get the disease, having a family member with the disease increases your risk. Studies show that psoriasis and psoriatic arthritis have a strong genetic impact. Both psoriasis and psoriatic arthritis are complex genetic diseases with a significant genetic component. Although there are different types of psoriasis, most genetic research has been on patients with chronic plaque psoriasis, which is the most common one. Research about the genetics of psoriasis began in the early 1970s. However, in recent years it has expanded its scope, thanks to improvements in medical and genetic technology, and increased funding.

It was found that there is a higher incidence of psoriasis in relatives of patients with psoriasis compared to the general population.

  • You have about a 10 percent chance of getting psoriasis, if one of your parents has it.
  • You're at 50 percent risk of getting psoriasis if both your parents have it.
  • Compared to the general population, you are four to six times more likely to get psoriasis, if you have a sibling with the disease.

Although you may not argue that psoriasis is hereditary, you may ask yourself whether the genes of people with psoriasis and psoriatic arthritis are more likely than others to get these diseases than others?

Some possible genetic changes could explain why psoriasis and psoriatic arthritis develops. At least 10% of the general population inherits one or more of the genes associated with psoriasis. However, the disease may only outbreak in about 2% to 3% of the population − those with the genetic mix that also get exposed to triggers that lead to the development of psoriasis. It may be that people with no family history have a genetic disease because they inherited two genes from their father and two genes from their mother, whom never developed the disease.

A published study using genetic material from the National Psoriasis Victor Henschel BioBank has identified a gene directly associated with plaque psoriasis. The Victor Henschel BioBank is a collection of DNA samples and clinical information used to advance psoriasis genetic research. Anne Bowcock, main author and researcher of the study, revealed a rare mutation in the CARD14 gene that leads to plaque psoriasis, when activated by an environmental trigger. The researchers noted that the mutation is not necessarily inherited, but can occur spontaneously. According to Bowcock, the finding of a single gene linked to plaque psoriasis is significant and will contribute to the developments of new treatments, as it proves that the CARD14 gene itself, together with an environmental trigger such as an infection, can cause psoriasis.

If you are suffering from psoriasis, you are probably asking yourself "why me?"

Well, the answer to that lies in psoriasis genetic research, which is most important in identifying the cause of the disease. Exploring all the genetic factors that are causing the disease will shed light on why some people get psoriasis and others don't. Although it might not be comforting to you, genetic research can better control psoriasis through more precise and effective treatments, and that's the good news! Understanding how people with psoriasis are genetically different from people who are not, may enable scientists to create treatments that fix the behavior of cells. Or, they may be able to fix the differences in the genes themselves.

If you are looking for a research-based topical treatment, then DermaZor may be the right treatment for you. DermaZor is the only patented, over-the-counter (OTC) treatment, recognized by the National Psoriasis Foundation, that combines the healing properties of cannabis with all natural, multi-acting ingredients. Clinically tested, DermaZor® has proven efficacy in the treatment of skin disorders, relieving symptoms and restoring the skin to its natural and healthy state.

Several studies suggest cannabis may help slow the rapid growth of keratinocytes. It is thought that these immature skin cells are the cause of raised patches and silver scales that characterizes psoriasis. A recent study found that cannabinoids and their receptors may help control and limit the production of these immature skin cells. Researchers further added that cannabis may be useful in treating several conditions involving keratinocytes, including psoriasis. Furthermore, Cannabis in the form of oil for topical psoriasis treatment may also help control the speed of skin cell production and reduce inflammation.


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